Efficacy of Topiramate in Children with Refractory Status Epilepticus
نویسندگان
چکیده
منابع مشابه
Efficacy of topiramate in children with refractory status epilepticus.
PURPOSE Status epilepticus (SE) is a life-threatening medical condition associated with significant morbidity and mortality that requires urgent medical intervention. Although several agents are available to treat SE, they occasionally fail to abort seizure activity. Topiramate (TPM) was anecdotally reported to be effective in adult patients with refractory SE. In this study, we evaluated the e...
متن کاملThe Efficacy of Propofol and Midazolam in Treatment of Refractory Status Epilepticus in Children
Background: In this study, we compared the efficacy and safety of propofol and midazolam in treatment of children’s refractory status epilepticus. Methods: We recruited 32 patients with refractory status epilepticus. Of those, 16 were treated primarily with midazolam and 16 received propofol. Results: We achieved complete seizure control in 6 (38%) patients treated by midazolam, and in 10 (63%)...
متن کاملAssessing the value of topiramate in refractory status epilepticus
PURPOSE The aim of this study was to assess factors associated with the use of topiramate (TPM) in refractory status epilepticus (RSE). METHODS We retrospectively reviewed RSE episodes over a 12-year period. Episodes treated with and without TPM were compared in terms of demographics, RSE characteristics, clinical course, and outcome in univariate and multivariate analyses. Subgroups defined ...
متن کاملThe use of topiramate in refractory status epilepticus.
In cases of refractory status epilepticus (RSE) unresponsive to sequential trials of multiple agents, a suspension of topiramate administered via nasogastric tube was effective in aborting RSE, including one patient in a prolonged pentobarbital coma. Effective dosages ranged from 300 to 1,600 mg/d. Except for lethargy, no adverse events were reported.
متن کاملthe efficacy of propofol and midazolam in treatment of refractory status epilepticus in children
background: in this study, we compared the efficacy and safety of propofol and midazolam in treatment of children’s refractory status epilepticus. methods: we recruited 32 patients with refractory status epilepticus. of those, 16 were treated primarily with midazolam and 16 received propofol. results: we achieved complete seizure control in 6 (38%) patients treated by midazolam, and in 10 (...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2003
ISSN: 0013-9580,1528-1167
DOI: 10.1046/j.1528-1157.2003.11803.x